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The overall goal of the consortium is to optimize and standardize islet transplantation. Specifically the consortium will aim:
to improve donor management, donor selection criteria, organ recovery techniques and islet cell processing techniques.
Expected results: identification of more efficient islet cell processing to maximize islet recovery.
to identify and standardize methods for the evaluation of islet preparations intended for transplantation in humans (ie cell composition, cell viability, insulin secretion).
Expected results: identification and validation of predictor for islet engraftment and post-transplant function.
to identify strategies and drugs able to improve islet ‘engraftment’.
Expected results: achieve successful islet transplantation from one donor to one recipient
to develop multi centre clinical trial to test new immunosuppression and tolerogenic strategies
Expected results: achieve successful islet transplantation without immunosuppression or with less toxic immunosuppressive regimens.
provide islets for researchers.
Expected results: support research activity related to beta cell biology in Europe.